| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-BEX1 (2-35 aa) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB. A dilution of 1:200 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
BEX1 |
| Gene ID: |
55859 |
| Uniprot ID: |
BEX1_HUMAN |
| Immunogen Region: |
2-35 aa |
| Specificity: |
Specific for BEX1 (BEX2). |
| Immunogen: |
A synthetic peptide from aa region 2-35 of human BEX1 conjugated to blue carrier protein was used as the antigen. |
| Post Translational Modifications | Phosphorylated. Phosphorylation of Ser-102 protects it from the proteasome. Ubiquitinated. Degraded by the proteasome. |
| Function | Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states. In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates. |
| Protein Name | Protein Bex1Brain-Expressed X-Linked Protein 1 |
| Cellular Localisation | NucleusCytoplasmShuttles Between The Cytoplasm And The NucleusPredominantly Nuclear |
| Alternative Antibody Names | Anti-Protein Bex1 antibodyAnti-Brain-Expressed X-Linked Protein 1 antibodyAnti-BEX1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
