• Western blot analysis of various lysates using Beta 1-Adrenergic Receptor Rabbit polyclonal antibody (STJ11103471) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 3s.

Anti-Beta 1-Adrenergic Receptor antibody (350-450) (STJ11103471)

SKU:
STJ11103471

£112.50 - £522.50
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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Beta 1-Adrenergic Receptor (350-450) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ADRB1
Gene ID: 153
Uniprot ID: ADRB1_HUMAN
Immunogen Region: 350-450
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 350-450 of human Beta 1-Adrenergic Receptor (NP_000675.1).
Immunogen Sequence: HRELVPDRLFVFFNWLGYAN SAFNPIIYCRSPDFRKAFQG LLCCARRAARRRHATHGDRP RASGCLARPGPPPSPGAASD DDDDDVVGATPPARLLEPWA G
Post Translational Modifications Homologous desensitization of the receptor is mediated by its phosphorylation by beta-adrenergic receptor kinase.
Function Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling. Involved in the regulation of sleep/wake behaviors.
Protein Name Beta-1 Adrenergic Receptor
Beta-1 Adrenoreceptor
Beta-1 Adrenoceptor
Database Links Reactome: R-HSA-390696
Reactome: R-HSA-418555
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Early Endosome
Colocalizes With Rapgef2 At The Plasma Membrane
Localized At The Plasma Membrane
Found In The Golgi Upon Gopc Overexpression
Alternative Antibody Names Anti-Beta-1 Adrenergic Receptor antibody
Anti-Beta-1 Adrenoreceptor antibody
Anti-Beta-1 Adrenoceptor antibody
Anti-ADRB1 antibody
Anti-ADRB1R antibody
Anti-B1AR antibody

Information sourced from Uniprot.org

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