| Post Translational Modifications | Sumoylated at Lys-20 by SUMO1 and at Lys-512 by SUMO1, SUMO2 and SUMO3. Sumoylation probably occurs sequentially, with that of Lys-20 preceding that of Lys-512. It does not alter association with heterochromatin, but is required for the repression of transcription. |
| Function | Transcriptional repressor which associates with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription. The sumoylated form modulates the stability of the NoRC complex component BAZ2A/TIP5 by controlling its USP21-mediated deubiquitination. Binds to unmethylated major satellite DNA and is involved in the recruitment of the Polycomb repressive complex 2 (PRC2) to major satellites. Stimulates the ERCC6L translocase and ATPase activities. |
| Protein Name | Ben Domain-Containing Protein 3 |
| Cellular Localisation | NucleusNucleolusIn The NucleusObserved In Heterochromatic Foci Containing Cbx1Cbx3Cbx5 And Histone H3 Trimethylated At 'Lys-9'Released From Chromatin During DecondensationAssociation With Heterochromatin Does Not Depend On Sumoylation |
| Alternative Antibody Names | Anti-Ben Domain-Containing Protein 3 antibodyAnti-BEND3 antibodyAnti-KIAA1553 antibody |
Information sourced from Uniprot.org
