| Tissue Specificity | Expressed at high levels in brain, spleen thymus, bone marrow and testis. Expressed in CD34-positive myeloid precursor cells, B-cells, monocytes and megakaryocytes. Expression is tightly regulated during B-cell development. Isoform 1: Expressed in fetal and adult brain, and in the plasmacytoid dendritic cell. |
| Post Translational Modifications | Sumoylated with SUMO1. |
| Function | Transcription factor. Associated with the BAF SWI/SNF chromatin remodeling complex. Binds to the 5'-TGACCA-3' sequence motif in regulatory regions of target genes, including a distal promoter of the HBG1 hemoglobin subunit gamma-1 gene. Involved in regulation of the developmental switch from gamma- to beta-globin, probably via direct repression of HBG1.hence indirectly repressing fetal hemoglobin (HbF) level. Involved in brain development. May play a role in hematopoiesis. Essential factor in lymphopoiesis required for B-cell formation in fetal liver. May function as a modulator of the transcriptional repression activity of NR2F2. |
| Protein Name | B-Cell Lymphoma/Leukemia 11aBcl-11aB-Cell Cll/Lymphoma 11aCoup-Tf-Interacting Protein 1Ecotropic Viral Integration Site 9 Protein HomologEvi-9Zinc Finger Protein 856 |
| Database Links | Reactome: R-HSA-9700645Reactome: R-HSA-9725370 |
| Cellular Localisation | CytoplasmNucleusChromosomeAssociates With The Nuclear BodyColocalizes With Sumo1 And Senp2 In Nuclear SpecklesIsoform 1: Nucleus MatrixColocalizes With Bcl6 In Nuclear ParaspecklesIsoform 2: CytoplasmPredominantly Localized In The Nucleus In Nuclear ParaspecklesIsoform 3: CytoplasmPredominantly Localized In The Cytoplasm In The Absence Of Interaction With Isoform 1 And Isoform 2In Presence Of Isoform 1 Or Isoform 2Translocates From The Cytoplasm Into Nuclear Paraspeckles |
| Alternative Antibody Names | Anti-B-Cell Lymphoma/Leukemia 11a antibodyAnti-Bcl-11a antibodyAnti-B-Cell Cll/Lymphoma 11a antibodyAnti-Coup-Tf-Interacting Protein 1 antibodyAnti-Ecotropic Viral Integration Site 9 Protein Homolog antibodyAnti-Evi-9 antibodyAnti-Zinc Finger Protein 856 antibodyAnti-BCL11A antibodyAnti-CTIP1 antibodyAnti-EVI9 antibodyAnti-KIAA1809 antibodyAnti-ZNF856 antibody |
Information sourced from Uniprot.org
