Anti-BCCIP antibody (1-314) (STJ111319)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal BCCIP (1-314) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:100-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | BCCIP |
| Gene ID | 56647 |
| Uniprot ID | BCCIP_HUMAN |
| Immunogen Region | 1-314 |
| Immunogen Sequence | MASRSKRRAVESGVPQPPDP PVQRDEEEEKEVENEDEDDD DSDKEKDEEDEVIDEEVNIE FEAYSLSDNDYDGIKKLLQQ LFLKAPVNTAELTDLLIQQN HIGSVIKQTDVSEDSNDDMD EDEVFGFISLLNLTERKGTQ CVEQIQELVLRFCEKNCEKS MVEQLDKFLNDTTKPVGLLL SERFINVPPQIALPMYQQLQ KELAGAHRTNKPCGKCYFYL LISKTFVEAGKNNSKKKPS |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-314 of human BCCIP (NP_510868.1). |
Additional Info
| Tissue Specificity | Expressed at high levels in testis and skeletal muscle and at lower levels in brain, heart, kidney, liver, lung, ovary, pancreas, placenta, and spleen. |
| Function | During interphase, required for microtubule organizing and anchoring activities. During mitosis, required for the organization and stabilization of the spindle pole. Isoform 2/alpha is particularly important for the regulation of microtubule anchoring, microtubule stability, spindle architecture and spindle orientation, compared to isoform 1/beta. May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ). |
| Protein Name | Brca2 And Cdkn1a-Interacting ProteinP21- And Cdk-Associated Protein 1Protein Tok-1 |
| Database Links | |
| Cellular Localisation | NucleusCytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeCentrioleSpindle PoleColocalizes With Brca2 In Discrete Nuclear FociIn InterphasePreferential Localizes To The Mother CentrioleRecruited To The Spindle Pole Matrix And Centrosome By Microtubules And Dynein/Dynactin ActivityIsoform 1: CytoplasmIsoform 1/Beta Tends To Be Less Abundant AtAnd Less Strongly Associated WithCentrosomes Than Isoform 2/AlphaIsoform 2: CytoplasmIsoform 2/Alpha Tends To Be More Abundant AtAnd More Strongly Associated WithCentrosomes Than Isoform 1/Beta |
| Alternative Antibody Names | Anti-Brca2 And Cdkn1a-Interacting Protein antibodyAnti-P21- And Cdk-Associated Protein 1 antibodyAnti-Protein Tok-1 antibodyAnti-BCCIP antibodyAnti-TOK1 antibody |
Information sourced from Uniprot.org