| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S9MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 IHC-P:1:50-1:200 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | BCAP31 |
| Gene ID: | 10134 |
| Uniprot ID: | BAP31_HUMAN |
| Immunogen Region: | 101-200 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 101-200 of human BAP31 (P51572). |
| Immunogen Sequence: | RNLYIAGFSLLLSFLLRRLV TLISQQATLLASNEAFKKQA ESASEAAKKYMEENDQLKKG AAVDGGKLDVGNAEVKLEEE NRSLKADLQKLKDELASTKQ |
| Tissue Specificity | Ubiquitous. Highly expressed in neurons and discrete endocrine cells. |
| Post Translational Modifications | Cleaved by CASP8 and other caspases. |
| Function | Functions as a chaperone protein. Is one of the most abundant endoplasmic reticulum (ER) proteins. Plays a role in the export of secreted proteins in the ER, the recognition of abnormally folded protein and their targeting to the ER associated-degradation (ERAD). Also serves as a cargo receptor for the export of transmembrane proteins. Plays a role in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) by stimulating the translocation of NDUFS4 and NDUFB11 from the cytosol to the mitochondria via interaction with TOMM40. In response to ER stress, delocalizes from the ER-mitochondria contact sites and binds BCL2. May be involved in CASP8-mediated apoptosis. |
| Protein Name | B-Cell Receptor-Associated Protein 31 Bcr-Associated Protein 31 Bap31 6c6-Ag Tumor-Associated Antigen Protein Cdm P28 |
| Database Links | Reactome: R-HSA-111465 Reactome: R-HSA-75153 Reactome: R-HSA-8980692 Reactome: R-HSA-983170 Reactome: R-HSA-9833110 |
| Cellular Localisation | Endoplasmic Reticulum Membrane Multi-Pass Membrane Protein Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane May Shuttle Between The Er And The Intermediate Compartment/Cis-Golgi Complex Associates With The Mitochondria-Associated Endoplasmic Reticulum Membrane Via Interaction With Tomm40 (Microbial Infection) Upon Sv40 Infection Colocalizes With Dnajc18 Dnajb12 And Dnajb14 In Punctate Structures Within The Endoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-B-Cell Receptor-Associated Protein 31 antibody Anti-Bcr-Associated Protein 31 antibody Anti-Bap31 antibody Anti-6c6-Ag Tumor-Associated Antigen antibody Anti-Protein Cdm antibody Anti-P28 antibody Anti-BCAP31 antibody Anti-BAP31 antibody Anti-DXS1357E antibody |
Information sourced from Uniprot.org