| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-PUMA is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS + 0.02% NaN3 |
| Purification: | Antigen Affinity Purified |
| Dilution Range: | WB 1:500-1:1000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | BBC3 |
| Gene ID: | 27113 |
| Uniprot ID: | BBC3_HUMAN |
| Specificity: | Reacts with a sequence found in the exon-3-encoded region in the human PUMA-a and PUMA-b forms of the protein. Recognizes both forms of the protein |
| Immunogen: | Synthetic peptide corresponding to amino acids from a sequence found in the exon-3-encoded region in the human PUMA-a and PUMA-b forms of the protein. |
| Function | Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis. Promotes partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53, releasing the bound p53/TP53 to induce apoptosis. Regulates ER stress-induced neuronal apoptosis. |
| Protein Name | Bcl-2-Binding Component 3 - Isoforms 1/2Jfy-1P53 Up-Regulated Modulator Of Apoptosis |
| Database Links | Reactome: R-HSA-111453Reactome: R-HSA-139915Reactome: R-HSA-6803204Reactome: R-HSA-9614657 |
| Cellular Localisation | MitochondrionLocalized To The Mitochondria In Order To Induce Cytochrome C Release |
| Alternative Antibody Names | Anti-Bcl-2-Binding Component 3 - Isoforms 1/2 antibodyAnti-Jfy-1 antibodyAnti-P53 Up-Regulated Modulator Of Apoptosis antibodyAnti-BBC3 antibodyAnti-PUMA antibody |
Information sourced from Uniprot.org
