| Host: | Goat |
| Applications: | Pep-ELISA/IHC |
| Reactivity: | Human/Mouse/Rat/Cow |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-BAZ2B (C-Term) is suitable for use in ELISA and Immunohistochemistry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:4000. WB: Preliminary experiments gave an approx 35kDa band in Testis and Brain lysates after 0.3µg/ml antibody staining. Please note that currently we cannot find an explanation in the literatur |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | BAZ2B |
| Gene ID: | 29994 |
| Uniprot ID: | BAZ2B_HUMAN |
| Immunogen Region: | C-Term |
| Accession Number: | NP_038478.2 |
| Immunogen Sequence: | YFEKKWTDTFKVS |
| Function | Regulatory subunit of the ATP-dependent BRF-1 and BRF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair. Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template. The BRF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the BRF-5 ISWI chromatin remodeling complex. Chromatin reader protein, which may play a role in transcriptional regulation via interaction with ISWI. Involved in positively modulating the rate of age-related behavioral deterioration. Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with histone methyltransferase EHMT1. |
| Protein Name | Bromodomain Adjacent To Zinc Finger Domain Protein 2b Hwalp4 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Bromodomain Adjacent To Zinc Finger Domain Protein 2b antibody Anti-Hwalp4 antibody Anti-BAZ2B antibody Anti-KIAA1476 antibody |
Information sourced from Uniprot.org