| Tissue Specificity | Down-regulated in breast cancer cell lines. |
| Post Translational Modifications | MAPK1/MAPK3-mediated phosphorylation at Thr-337 and Thr-352 results in export to the cytoplasm. |
| Function | Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 activation, which causes cell cycle arrest. Plays a role in the regulation of alternative splicing. Binds to CD44 pre-mRNA and negatively regulates the inclusion of CD44 proximal variable exons v2-v6 but has no effect on distal variable exons v7-v10. |
| Protein Name | Protein BanpBen Domain-Containing Protein 1Btg3-Associated Nuclear ProteinScaffold/Matrix-Associated Region-1-Binding Protein |
| Database Links | Reactome: R-HSA-6804759 |
| Cellular Localisation | NucleusNucleus SpeckleCytoplasmPrimarily Nuclear But Translocates To The Cytoplasm Following Mapk1/Mapk3-Mediated Phosphorylation |
| Alternative Antibody Names | Anti-Protein Banp antibodyAnti-Ben Domain-Containing Protein 1 antibodyAnti-Btg3-Associated Nuclear Protein antibodyAnti-Scaffold/Matrix-Associated Region-1-Binding Protein antibodyAnti-BANP antibodyAnti-BEND1 antibodyAnti-SMAR1 antibody |
Information sourced from Uniprot.org
![Chromatin immunoprecipitation analysis of extracts of HeLa cells, using [KD Validated] CTCF Rabbit polyclonal antibody (STJ11100563) and rabbit IgG. The amount of immunoprecipitated DNA was checked by quantitative PCR. Histogram was constructed by the ratios of the immunoprecipitated DNA to the input.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/89614/358098/STJ11100563_1__34552.1713122383.jpg?c=1 "Chromatin immunoprecipitation analysis of extracts of HeLa cells, using [KD Validated] CTCF Rabbit polyclonal antibody (STJ11100563) and rabbit IgG. The amount of immunoprecipitated DNA was checked by quantitative PCR. Histogram was constructed by the ratios of the immunoprecipitated DNA to the input.")
