| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | BAG5 |
| Gene ID: | 9529 |
| Uniprot ID: | BAG5_HUMAN |
| Immunogen Region: | 198-447 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 198-447 of human BAG5 (NP_004864.1). |
| Immunogen Sequence: | GVLIALLMGVNNNETCRHLS CVLSGLIADLDALDVCGRTE IRNYRREVVEDINKLLKYLD LEEEADTTKAFDLRQNHSIL KIEKVLKRMREIKNELLQAQ NPSELYLSSKTELQGLIGQL DEVSLEKNPCIREARRRAVI EVQTLITYIDLKEALEKRKL FACEEHPSHKAVWNVLGNLS EIQGEVLSFDGNRTDKNYIR LEELLTKQLLALDAVDPQGE EKCKAARKQAVRLAQNILS |
| Tissue Specificity | Expressed in the heart. |
| Function | Co-chaperone for HSP/HSP70 proteins. It functions as a nucleotide-exchange factor promoting the release of ADP from HSP70, thereby activating HSP70-mediated protein refolding. Has an essential role in maintaining proteostasis at junctional membrane complexes (JMC), where it may function as a scaffold between the HSPA8 chaperone and JMC proteins enabling correct, HSPA8-dependent JMC protein folding. Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN. |
| Protein Name | Bag Family Molecular Chaperone Regulator 5Bag-5Bcl-2-Associated Athanogene 5 |
| Database Links | Reactome: R-HSA-3371453 |
| Cellular Localisation | In CardiomyocytesLocalized At Specialized Membrane Contact Sites Between T-Tubules And The Sarcoplasmic ReticulumKnown As Junctional Membrane Complexes |
| Alternative Antibody Names | Anti-Bag Family Molecular Chaperone Regulator 5 antibodyAnti-Bag-5 antibodyAnti-Bcl-2-Associated Athanogene 5 antibodyAnti-BAG5 antibodyAnti-KIAA0873 antibody |
Information sourced from Uniprot.org