| Function | Co-chaperone and adapter protein that connects different classes of molecular chaperones including heat shock proteins 70 (HSP70s), e.g. HSPA1A/HSP70 or HSPA8/HSC70, and small heat shock proteins (sHSPs), e.g. HSPB8. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from HSP70s, thereby triggering client protein release. Nucleotide release is mediated via BAG3 binding to the nucleotide-binding domain (NBD) of HSP70s, whereas client release is mediated via binding to the substrate-binding domain (SBD). Has anti-apoptotic activity. Plays a role in the HSF1 nucleocytoplasmic transport. |
| Protein Name | Bag Family Molecular Chaperone Regulator 3Bag-3Bcl-2-Associated Athanogene 3Bcl-2-Binding Protein BisDocking Protein Cair-1 |
| Database Links | Reactome: R-HSA-3371453 |
| Cellular Localisation | NucleusCytoplasmColocalizes With Hsf1 To The Nucleus Upon Heat Stress |
| Alternative Antibody Names | Anti-Bag Family Molecular Chaperone Regulator 3 antibodyAnti-Bag-3 antibodyAnti-Bcl-2-Associated Athanogene 3 antibodyAnti-Bcl-2-Binding Protein Bis antibodyAnti-Docking Protein Cair-1 antibodyAnti-BAG3 antibodyAnti-BIS antibody |
Information sourced from Uniprot.org
