| Host: | Rabbit |
| Applications: | IHC/WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-BACE2 (460-518 aa) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Lyophilised |
| Purification: | IgG purified |
| Dilution Range: | IHC, WB. Use at a dilution of 1:200 to 1:2000. The optimal dilution should be determined by the end user. |
| Storage Instruction: | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: | BACE2 |
| Gene ID: | 25825 |
| Uniprot ID: | BACE2_HUMAN |
| Immunogen Region: | 460-518 aa |
| Specificity: | Specific for BACE2. |
| Immunogen: | A synthetic peptide from aa region 460-518 of human BACE2 conjugated to blue carrier protein has been used as the antigen. |
| Post Translational Modifications | Undergoes autoproteolytic cleavage. Glycosylated. |
| Function | Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. Involved in the proteolytic shedding of PMEL at early stages of melanosome biogenesis. Cleaves PMEL within the M-beta fragment to release the amyloidogenic PMEL luminal fragment containing M-alpha and a small portion of M-beta N-terminus. This is a prerequisite step for subsequent processing and assembly of PMEL fibrils into amyloid sheets. Responsible also for the proteolytic processing of CLTRN in pancreatic beta cells. |
| Protein Name | Beta-Secretase 2 Aspartic-Like Protease 56 Kda Aspartyl Protease 1 Asp1 Asp 1 Beta-Site Amyloid Precursor Protein Cleaving Enzyme 2 Beta-Site App Cleaving Enzyme 2 Down Region Aspartic Protease Drap Memapsin-1 Membrane-Associated Aspartic Protease 1 Theta-Secretase |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein Golgi Apparatus Endoplasmic Reticulum Endosome Melanosome Colocalizes With Pmel In Stage I And Ii Melanosomes |
| Alternative Antibody Names | Anti-Beta-Secretase 2 antibody Anti-Aspartic-Like Protease 56 Kda antibody Anti-Aspartyl Protease 1 antibody Anti-Asp1 antibody Anti-Asp 1 antibody Anti-Beta-Site Amyloid Precursor Protein Cleaving Enzyme 2 antibody Anti-Beta-Site App Cleaving Enzyme 2 antibody Anti-Down Region Aspartic Protease antibody Anti-Drap antibody Anti-Memapsin-1 antibody Anti-Membrane-Associated Aspartic Protease 1 antibody Anti-Theta-Secretase antibody Anti-BACE2 antibody Anti-AEPLC antibody Anti-ALP56 antibody Anti-ASP21 antibody Anti-CDA13 antibody Anti-UNQ418 antibody Anti-PRO852 antibody |
Information sourced from Uniprot.org
