| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-BACE2 (100-150 aa) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB. Use at a dilution of 1:200 to 1:2000. The optimal dilution should be determined by the end user. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
BACE2 |
| Gene ID: |
25825 |
| Uniprot ID: |
BACE2_HUMAN |
| Immunogen Region: |
100-150 aa |
| Specificity: |
Specific for BACE2. |
| Immunogen: |
A synthetic peptide from aa region 100-150 of human BACE2 conjugated to an immunogenic carrier protein has been used as the antigen. |
| Post Translational Modifications | Undergoes autoproteolytic cleavage. Glycosylated. |
| Function | Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. Involved in the proteolytic shedding of PMEL at early stages of melanosome biogenesis. Cleaves PMEL within the M-beta fragment to release the amyloidogenic PMEL luminal fragment containing M-alpha and a small portion of M-beta N-terminus. This is a prerequisite step for subsequent processing and assembly of PMEL fibrils into amyloid sheets. Responsible also for the proteolytic processing of CLTRN in pancreatic beta cells. |
| Protein Name | Beta-Secretase 2Aspartic-Like Protease 56 KdaAspartyl Protease 1Asp1Asp 1Beta-Site Amyloid Precursor Protein Cleaving Enzyme 2Beta-Site App Cleaving Enzyme 2Down Region Aspartic ProteaseDrapMemapsin-1Membrane-Associated Aspartic Protease 1Theta-Secretase |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinGolgi ApparatusEndoplasmic ReticulumEndosomeMelanosomeColocalizes With Pmel In Stage I And Ii Melanosomes |
| Alternative Antibody Names | Anti-Beta-Secretase 2 antibodyAnti-Aspartic-Like Protease 56 Kda antibodyAnti-Aspartyl Protease 1 antibodyAnti-Asp1 antibodyAnti-Asp 1 antibodyAnti-Beta-Site Amyloid Precursor Protein Cleaving Enzyme 2 antibodyAnti-Beta-Site App Cleaving Enzyme 2 antibodyAnti-Down Region Aspartic Protease antibodyAnti-Drap antibodyAnti-Memapsin-1 antibodyAnti-Membrane-Associated Aspartic Protease 1 antibodyAnti-Theta-Secretase antibodyAnti-BACE2 antibodyAnti-AEPLC antibodyAnti-ALP56 antibodyAnti-ASP21 antibodyAnti-CDA13 antibodyAnti-UNQ418 antibodyAnti-PRO852 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
