| Post Translational Modifications | N-Glycosylated. Addition of a bisecting N-acetylglucosamine by MGAT3 blocks lysosomal targeting, further degradation and is required for maintaining stability under stress conditions. Acetylated in the endoplasmic reticulum at Lys-126, Lys-275, Lys-279, Lys-285, Lys-299, Lys-300 and Lys-307. Acetylation by NAT8 and NAT8B is transient and deacetylation probably occurs in the Golgi. Acetylation regulates the maturation, the transport to the plasma membrane, the stability and the expression of the protein. Palmitoylation mediates lipid raft localization. Ubiquitinated at Lys-501, ubiquitination leads to lysosomal degradation. Monoubiquitinated and 'Lys-63'-linked polyubitinated. Deubiquitnated by USP8.inhibits lysosomal degradation. Phosphorylation at Ser-498 is required for interaction with GGA1 and retrograded transport from endosomal compartments to the trans-Golgi network. Non-phosphorylated BACE1 enters a direct recycling route to the cell surface. |
| Function | Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. Cleaves CHL1. |
| Protein Name | Beta-Secretase 1Aspartyl Protease 2Asp2Asp 2Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1Beta-Site App Cleaving Enzyme 1Memapsin-2Membrane-Associated Aspartic Protease 2 |
| Database Links | Reactome: R-HSA-977225 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinGolgi ApparatusTrans-Golgi NetworkEndoplasmic ReticulumEndosomeCell SurfaceCytoplasmic Vesicle MembraneMembrane RaftLysosomeLate EndosomeEarly EndosomeRecycling EndosomeCell ProjectionAxonDendritePredominantly Localized To The Later Golgi/Trans-Golgi Network (Tgn) And Minimally Detectable In The Early Golgi CompartmentsA Small Portion Is Also Found In The Endoplasmic ReticulumEndosomes And On The Cell SurfaceColocalization With App In Early Endosomes Is Due To Addition Of Bisecting N-Acetylglucosamine Wich Blocks Targeting To Late Endosomes And LysosomesRetrogradly Transported From Endosomal Compartments To The Trans-Golgi Network In A Phosphorylation- And Gga1- Dependent Manner |
| Alternative Nanobody Names | Anti-Beta-Secretase 1 nanobodyAnti-Aspartyl Protease 2 nanobodyAnti-Asp2 nanobodyAnti-Asp 2 nanobodyAnti-Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 nanobodyAnti-Beta-Site App Cleaving Enzyme 1 nanobodyAnti-Memapsin-2 nanobodyAnti-Membrane-Associated Aspartic Protease 2 nanobodyAnti-BACE1 nanobodyAnti-BACE nanobodyAnti-KIAA1149 nanobody |
Information sourced from Uniprot.org
![Anti-BACE1 nanobody [SAA1336] (STJN000238)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/200851/413033/STJN000238-SDS-PAGE-1__21721.1749232548.jpg?c=1 "Anti-BACE1 nanobody [SAA1336] (STJN000238)")
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