| Tissue Specificity | Overexpressed in breast, ovarian, endometrial, renal cell (RCC) and non-small-cell lung cancers (NSCLC). Expressed on activated T- and B-cells, monocytes and dendritic cells, but not expressed in most normal tissues (at protein level). Widely expressed, including in kidney, liver, lung, ovary, placenta, spleen and testis. |
| Post Translational Modifications | N-glycosylated. |
| Function | Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation. |
| Protein Name | V-Set Domain-Containing T-Cell Activation Inhibitor 1B7 Homolog 4B7-H4B7h.5Immune Costimulatory Protein B7-H4Protein B7s1T-Cell Costimulatory Molecule B7x |
| Database Links | |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinExpressed At The Cell SurfaceA Soluble Form Has Also Been Detected |
| Alternative Antibody Names | Anti-V-Set Domain-Containing T-Cell Activation Inhibitor 1 antibodyAnti-B7 Homolog 4 antibodyAnti-B7-H4 antibodyAnti-B7h.5 antibodyAnti-Immune Costimulatory Protein B7-H4 antibodyAnti-Protein B7s1 antibodyAnti-T-Cell Costimulatory Molecule B7x antibodyAnti-VTCN1 antibodyAnti-B7H4 antibodyAnti-UNQ659 antibodyAnti-PRO1291 antibody |
Information sourced from Uniprot.org
