| Host: | Goat |
| Applications: | Pep-ELISA/WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-B56 beta isoform-Isoform Beta (C-Term) is suitable for use in ELISA and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:2000.WB: Approx. 55kDa band observed in Human Brain (Cerebellum) lysates (calculated MW of 57.4kDa according to NP_006235.1). Recommended concentration: 2-3µg/ml. Primary incubation was 1 hour. |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | PPP2R5B |
| Gene ID: | 5526 |
| Uniprot ID: | 2A5B_HUMAN |
| Immunogen Region: | C-Term |
| Accession Number: | NP_006235.1 |
| Immunogen Sequence: | QRLTPQVAASGGQS |
| Post Translational Modifications | Ubiquitinated by E3 CUL3-KLHL15 complex.this modification leads to proteasomal degradation. |
| Function | As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localization, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation. |
| Protein Name | Serine/Threonine-Protein Phosphatase 2a 56 Kda Regulatory Subunit Beta IsoformPp2a B Subunit Isoform B'-BetaPp2a B Subunit Isoform B56-BetaPp2a B Subunit Isoform Pr61-BetaPp2a B Subunit Isoform R5-Beta |
| Database Links | Reactome: R-HSA-141444Reactome: R-HSA-195253Reactome: R-HSA-196299Reactome: R-HSA-2467813Reactome: R-HSA-2500257Reactome: R-HSA-381038Reactome: R-HSA-389513Reactome: R-HSA-432142Reactome: R-HSA-4641262Reactome: R-HSA-5339716Reactome: R-HSA-5358747Reactome: R-HSA-5358749Reactome: R-HSA-5358751Reactome: R-HSA-5358752Reactome: R-HSA-5467337Reactome: R-HSA-5467340Reactome: R-HSA-5467348Reactome: R-HSA-5663220Reactome: R-HSA-5673000Reactome: R-HSA-5675221Reactome: R-HSA-6811558Reactome: R-HSA-68877Reactome: R-HSA-9648025 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Phosphatase 2a 56 Kda Regulatory Subunit Beta Isoform antibodyAnti-Pp2a B Subunit Isoform B'-Beta antibodyAnti-Pp2a B Subunit Isoform B56-Beta antibodyAnti-Pp2a B Subunit Isoform Pr61-Beta antibodyAnti-Pp2a B Subunit Isoform R5-Beta antibodyAnti-PPP2R5B antibody |
Information sourced from Uniprot.org
