Host: |
Rabbit |
Applications: |
IF |
Reactivity: |
Human |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: |
Rabbit polyclonal antibody anti-Axin-2 (700-800) is suitable for use in Immunofluorescence research applications. |
Clonality: |
Polyclonal |
Conjugation: |
Unconjugated |
Isotype: |
IgG |
Formulation: |
PBS with 0.01% thimerosal, 50% Glycerol, pH7.3. |
Purification: |
Affinity purification |
Dilution Range: |
IF/ICC 1:50-1:200 |
Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: |
AXIN2 |
Gene ID: |
8313 |
Uniprot ID: |
AXIN2_HUMAN |
Immunogen Region: |
700-800 |
Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 700-800 of human AXIN2 (NP_004646.3). |
Immunogen Sequence: |
ACRRLAEVSKPPKQRCCVAS QQRDRNHSATVQTGATPFSN PSLAPEDHKEPKKLAGVHAL QASELVVTYFFCGEEIPYRR MLKAQSLTLGHFKEQLSKKG N |
Tissue Specificity | Expressed in brain and lymphoblast. |
Post Translational Modifications | Probably phosphorylated by GSK3B and dephosphorylated by PP2A. ADP-ribosylated by tankyrase TNKS and TNKS2. Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination and subsequent activation of the Wnt signaling pathway. Ubiquitinated by RNF146 when poly-ADP-ribosylated, leading to its degradation and subsequent activation of the Wnt signaling pathway. Deubiquitinated by USP34, deubiquitinated downstream of beta-catenin stabilization step: deubiquitination is important Wnt signaling to positively regulate beta-catenin (CTNBB1)-mediated transcription. |
Function | Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B. |
Protein Name | Axin-2Axin-Like ProteinAxilAxis Inhibition Protein 2Conductin |
Database Links | Reactome: R-HSA-201681Reactome: R-HSA-4411364Reactome: R-HSA-4641257Reactome: R-HSA-5689880 |
Cellular Localisation | Cytoplasm |
Alternative Antibody Names | Anti-Axin-2 antibodyAnti-Axin-Like Protein antibodyAnti-Axil antibodyAnti-Axis Inhibition Protein 2 antibodyAnti-Conductin antibodyAnti-AXIN2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance