| Post Translational Modifications | Activated by phosphorylation at Thr-288.this brings about a change in the conformation of the activation segment. Phosphorylation at Thr-288 varies during the cell cycle and is highest during M phase. Autophosphorylated at Thr-288 upon TPX2 binding. Thr-288 can be phosphorylated by several kinases, including PAK and PKA. Protein phosphatase type 1 (PP1) binds AURKA and inhibits its activity by dephosphorylating Thr-288 during mitosis. Phosphorylation at Ser-342 decreases the kinase activity. PPP2CA controls degradation by dephosphorylating Ser-51 at the end of mitosis. Ubiquitinated by the E3 ubiquitin-protein ligase complex SCF(FBXL7) during mitosis, leading to its degradation by the proteasome. Ubiquitinated by CHFR, leading to its degradation by the proteasome. Ubiquitinated by the anaphase-promoting complex (APC), leading to its degradation by the proteasome. Ubiquitinated by the CUL3-KLHL18 ligase leading to its activation at the centrosome which is required for initiating mitotic entry. Ubiquitination mediated by CUL3-KLHL18 ligase does not lead to its degradation by the proteasome. |
| Function | Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Important for microtubule formation and/or stabilization. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and destabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Inhibits cilia outgrowth. Required for cilia disassembly via phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin. Regulates protein levels of the anti-apoptosis protein BIRC5 by suppressing the expression of the SCF(FBXL7) E3 ubiquitin-protein ligase substrate adapter FBXL7 through the phosphorylation of the transcription factor FOXP1. |
| Protein Name | Aurora Kinase AAurora 2Aurora/Ipl1-Related Kinase 1Ark-1Aurora-Related Kinase 1Breast Tumor-Amplified KinaseIpl1- And Aurora-Related Kinase 1Serine/Threonine-Protein Kinase 15Serine/Threonine-Protein Kinase 6Serine/Threonine-Protein Kinase Ayk1Serine/Threonine-Protein Kinase Aurora-A |
| Database Links | Reactome: R-HSA-174178Reactome: R-HSA-2565942Reactome: R-HSA-4615885Reactome: R-HSA-6804114Reactome: R-HSA-6804756Reactome: R-HSA-8854050Reactome: R-HSA-8854518Reactome: R-HSA-8854521 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeSpindle PoleCentrioleCell ProjectionNeuron ProjectionCiliumCilium Basal BodyBasolateral Cell MembraneDetected At The Neurite Hillock In Developing NeuronsLocalizes At The Centrosome In Mitotic Cells From Early Prophase Until TelophaseBut Also Localizes To The Spindle Pole Mts From Prophase To AnaphaseColocalized With Sirt2 At CentrosomeMoves To The Midbody During Both Telophase And CytokinesisAssociates With Both The Pericentriolar Material (Pcm) And CentriolesThe Localization To The Spindle Poles Is Regulated By Aaas |
| Alternative Nanobody Names | Anti-Aurora Kinase A nanobodyAnti-Aurora 2 nanobodyAnti-Aurora/Ipl1-Related Kinase 1 nanobodyAnti-Ark-1 nanobodyAnti-Aurora-Related Kinase 1 nanobodyAnti-Breast Tumor-Amplified Kinase nanobodyAnti-Ipl1- And Aurora-Related Kinase 1 nanobodyAnti-Serine/Threonine-Protein Kinase 15 nanobodyAnti-Serine/Threonine-Protein Kinase 6 nanobodyAnti-Serine/Threonine-Protein Kinase Ayk1 nanobodyAnti-Serine/Threonine-Protein Kinase Aurora-A nanobodyAnti-AURKA nanobodyAnti-AIK nanobodyAnti-AIRK1 nanobodyAnti-ARK1 nanobodyAnti-AURA nanobodyAnti-AYK1 nanobodyAnti-BTAK nanobodyAnti-IAK1 nanobodyAnti-STK15 nanobodyAnti-STK6 nanobody |
Information sourced from Uniprot.org
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