| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ATXN2 |
| Gene ID: | 6311 |
| Uniprot ID: | ATX2_HUMAN |
| Immunogen Region: | 1250-1331 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 1250-1331 of human ATXN2 (NP_002964.3). |
| Immunogen Sequence: | HVQSGMVPSHPTAHAPMMLM TTQPPGGPQAALAQSALQPI PVSTTAHFPYMTHPSVQAHH QQQL |
| Tissue Specificity | Expressed in the brain, heart, liver, skeletal muscle, pancreas and placenta. Isoform 1 is predominant in the brain and spinal cord. Isoform 4 is more abundant in the cerebellum. In the brain, broadly expressed in the amygdala, caudate nucleus, corpus callosum, hippocampus, hypothalamus, substantia nigra, subthalamic nucleus and thalamus. |
| Function | Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. |
| Protein Name | Ataxin-2Spinocerebellar Ataxia Type 2 ProteinTrinucleotide Repeat-Containing Gene 13 Protein |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Ataxin-2 antibodyAnti-Spinocerebellar Ataxia Type 2 Protein antibodyAnti-Trinucleotide Repeat-Containing Gene 13 Protein antibodyAnti-ATXN2 antibodyAnti-ATX2 antibodyAnti-SCA2 antibodyAnti-TNRC13 antibody |
Information sourced from Uniprot.org