| Post Translational Modifications | Exhibits variability in chain length, mitochondria have distinct pools of protein cleaved after the 24th, 25th, and 26th amino acid. |
| Function | Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase. Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing FECH to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme. |
| Protein Name | Atpase Inhibitor - MitochondrialAtp Synthase F1 Subunit EpsilonInhibitor Of F(1f(O-AtpaseIf(1If1 |
| Database Links | |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-Atpase Inhibitor - Mitochondrial antibodyAnti-Atp Synthase F1 Subunit Epsilon antibodyAnti-Inhibitor Of F(1f(O-Atpase antibodyAnti-If(1 antibodyAnti-If1 antibodyAnti-ATP5IF1 antibodyAnti-ATPI antibodyAnti-ATPIF1 antibody |
Information sourced from Uniprot.org
![Western blot analysis of lysates from wild type (WT) and ATPIF1 knockout (KO) 293T cells, using [KO Validated] ATPIF1 Rabbit polyclonal antibody (STJ11100822) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/89758/358234/STJ11100822_1__18532.1713122566.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and ATPIF1 knockout (KO) 293T cells, using [KO Validated] ATPIF1 Rabbit polyclonal antibody (STJ11100822) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.")
![Western blot analysis of lysates from wild type (WT) and ATPIF1 knockout (KO) 293T cells, using [KO Validated] ATPIF1 Rabbit polyclonal antibody (STJ11100822) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/89758/358234/STJ11100822_1__18532.1713122566.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and ATPIF1 knockout (KO) 293T cells, using [KO Validated] ATPIF1 Rabbit polyclonal antibody (STJ11100822) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.")
