| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ATP6V0C |
| Gene ID: | 527 |
| Uniprot ID: | VATL_HUMAN |
| Immunogen Region: | 37-50 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ATP6V0C (NP_001185498.1). |
| Immunogen Sequence: | MSESKSGPEYASFFAVMGAS AAMVFSALGAAYGTAKSGTG IAAMSVMRPEQIMKSIIPVV MAGIIAIYGLVVAVLIANSL NDDISLYKSFLQLGAGLSVG |
| Post Translational Modifications | Ubiquitinated by RNF182, leading to its degradation via the ubiquitin-proteasome pathway. |
| Function | Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments, and in some cell types, it is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. |
| Protein Name | V-Type Proton Atpase 16 Kda Proteolipid Subunit C V-Atpase 16 Kda Proteolipid Subunit C Vacuolar Proton Pump 16 Kda Proteolipid Subunit C |
| Database Links | Reactome: R-HSA-1222556 Reactome: R-HSA-6798695 Reactome: R-HSA-77387 Reactome: R-HSA-917977 Reactome: R-HSA-9639288 Reactome: R-HSA-983712 Reactome: R-HSA-9857377 |
| Cellular Localisation | Cytoplasmic Vesicle Clathrin-Coated Vesicle Membrane Multi-Pass Membrane Protein Secretory Vesicle Synaptic Vesicle Membrane |
| Alternative Antibody Names | Anti-V-Type Proton Atpase 16 Kda Proteolipid Subunit C antibody Anti-V-Atpase 16 Kda Proteolipid Subunit C antibody Anti-Vacuolar Proton Pump 16 Kda Proteolipid Subunit C antibody Anti-ATP6V0C antibody Anti-ATP6C antibody Anti-ATP6L antibody Anti-ATPL antibody |
Information sourced from Uniprot.org