| Tissue Specificity | Expressed in the central nervous system and in dorsal root ganglia neurons. Expressed in peripheral tissues (at protein level). |
| Function | Atlastin-3 (ATL3) is a membrane-anchored GTPase that mediates the GTP-dependent fusion of endoplasmic reticulum (ER) membranes, maintaining the continuous ER network. It facilitates the formation of three-way junctions where ER tubules intersect. Two atlastin-3 on neighboring ER tubules bind GTP and form loose homodimers through the GB1/RHD3-type G domains and 3HB regions. Upon GTP hydrolysis, the 3HB regions tighten, pulling the membranes together to drive their fusion. After fusion, the homodimer disassembles upon release of inorganic phosphate (Pi). Subsequently, GDP dissociates, resetting the monomers to a conformation ready for a new fusion cycle. |
| Protein Name | Atlastin-3At3Atl-3 |
| Database Links | |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinLocalizes To Endoplasmic Reticulum Tubules And Accumulates In Punctuate Structures Corresponding To 3-Way JunctionsWhich Represent Crossing-Points At Which The Tubules Build A Polygonal Network |
| Alternative Antibody Names | Anti-Atlastin-3 antibodyAnti-At3 antibodyAnti-Atl-3 antibodyAnti-ATL3 antibody |
Information sourced from Uniprot.org
