| Function | Atlastin-2 (ATL2) is a membrane-anchored GTPase that mediates the GTP-dependent fusion of endoplasmic reticulum (ER) membranes, maintaining the continuous ER network. It facilitates the formation of three-way junctions where ER tubules intersect. Two atlastin-2 on neighboring ER tubules bind GTP and form loose homodimers through the GB1/RHD3-type G domains and 3HB regions. Upon GTP hydrolysis, the 3HB regions tighten, pulling the membranes together to drive their fusion. After fusion, the homodimer disassembles upon release of inorganic phosphate (Pi). Subsequently, GDP dissociates, resetting the monomers to a conformation ready for a new fusion cycle. |
| Protein Name | Atlastin-2Atl-2Adp-Ribosylation Factor-Like Protein 6-Interacting Protein 2 |
| Database Links | |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinLocalizes At Endoplasmic Reticulum (Er) Three-Way Tubular Junctions |
| Alternative Antibody Names | Anti-Atlastin-2 antibodyAnti-Atl-2 antibodyAnti-Adp-Ribosylation Factor-Like Protein 6-Interacting Protein 2 antibodyAnti-ATL2 antibodyAnti-ARL6IP2 antibody |
Information sourced from Uniprot.org
