| Post Translational Modifications | Phosphorylated. Phosphorylation, by different kinases, of the N-terminal hypervariable region (HVR) regulates the ATL1-mediated membrane tethering step. |
| Function | Atlastin-1 (ATL1) is a membrane-anchored GTPase that mediates the GTP-dependent fusion of endoplasmic reticulum (ER) membranes, maintaining the continuous ER network. It facilitates the formation of three-way junctions where ER tubules intersect. Two atlastin-1 on neighboring ER tubules bind GTP and form loose homodimers through the GB1/RHD3-type G domains and 3HB regions. Upon GTP hydrolysis, the 3HB regions tighten, pulling the membranes together to drive their fusion. After fusion, the homodimer disassembles upon release of inorganic phosphate (Pi). Subsequently, GDP dissociates, resetting the monomers to a conformation ready for a new fusion cycle. May also regulate more or less directly Golgi biogenesis. Indirectly regulates axonal development. |
| Protein Name | Atlastin-1Atl-1Brain-Specific Gtp-Binding ProteinGtp-Binding Protein 3Gbp-3Hgbp3Guanine Nucleotide-Binding Protein 3Spastic Paraplegia 3 Protein A |
| Database Links | |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinGolgi Apparatus MembraneCell ProjectionAxonLocalizes To Endoplasmic Reticulum Tubular Network |
| Alternative Antibody Names | Anti-Atlastin-1 antibodyAnti-Atl-1 antibodyAnti-Brain-Specific Gtp-Binding Protein antibodyAnti-Gtp-Binding Protein 3 antibodyAnti-Gbp-3 antibodyAnti-Hgbp3 antibodyAnti-Guanine Nucleotide-Binding Protein 3 antibodyAnti-Spastic Paraplegia 3 Protein A antibodyAnti-ATL1 antibodyAnti-GBP3 antibodyAnti-SPG3 antibodyAnti-SPG3A antibody |
Information sourced from Uniprot.org
