Anti-ATG2B antibody (1360-1600) (STJ110796)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ATG2B (1360-1600) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ATG2B |
| Gene ID | 55102 |
| Uniprot ID | ATG2B_HUMAN |
| Immunogen Region | 1360-1600 |
| Immunogen Sequence | IQYIASYGDLQTPNKADMKP GAFQRRSKVDSSGRSSSRGP VLPEADQQMLRDLMSDAMEE IDMQQGTSSVKPQANGVLDE KSQIQEPCCSDLFLFPDESG NVSQESGPTYASFSHHFISD AMTGVPTENDDFCILFAPKA AMQEKEEEPVIKIMVDDAIV IRDNYFSLPVNKTDTSKAPL HFPIPVIRYVVKEVSLVWHL YGGKDFGTVPPTSPAKSYIS PHSSPSHTPTRHGRNTVCG |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1360-1600 of human ATG2B (NP_060506.5). |
Additional Info
| Function | Lipid transfer protein required for both autophagosome formation and regulation of lipid droplet morphology and dispersion. Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion. Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion. Lipid transfer activity is enhanced by WDR45/WIPI4, which promotes ATG2B-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes. |
| Protein Name | Autophagy-Related Protein 2 Homolog B |
| Database Links | |
| Cellular Localisation | Preautophagosomal Structure MembranePeripheral Membrane ProteinLipid DropletEndoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Autophagy-Related Protein 2 Homolog B antibodyAnti-ATG2B antibodyAnti-C14orf103 antibody |
Information sourced from Uniprot.org