| Host: |
Rabbit |
| Applications: |
WB/IHC/IF/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Cyclic AMP-dependent transcription factor ATF-6 beta (401-450 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000ELISA 1:20000IF 1:50-200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ATF6B |
| Gene ID: |
1388 |
| Uniprot ID: |
ATF6B_HUMAN |
| Immunogen Region: |
401-450 aa |
| Specificity: |
ATF-6 Beta Polyclonal Antibody detects endogenous levels of ATF-6 Beta protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human ATF6B at the amino acid range 401-450 |
| Post Translational Modifications | N-glycosylated. During unfolded protein response, a fragment of approximately 60 kDa containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage is probably performed sequentially by site-1 (MBTPS1, S1P) and site-2 (MBTPS2, S2P) proteases. |
| Function | Cyclic AMP-dependent transcription factor ATF-6 beta: Precursor of the transcription factor form (Processed cyclic AMP-dependent transcription factor ATF-6 beta), which is embedded in the endoplasmic reticulum membrane. Endoplasmic reticulum stress promotes processing of this form, releasing the transcription factor form that translocates into the nucleus, where it activates transcription of genes involved in the unfolded protein response (UPR). Processed cyclic AMP-dependent transcription factor ATF-6 beta: Transcription factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER stress. Binds DNA on the 5'-CCACGA-3' half of the ER stress response element (ERSE) (5'-CCAATN(9)CCACGA-3') when NF-Y is bound to ERSE. |
| Protein Name | Cyclic Amp-Dependent Transcription Factor Atf-6 BetaCamp-Dependent Transcription Factor Atf-6 BetaActivating Transcription Factor 6 BetaAtf6-BetaProtein G13Camp Response Element-Binding Protein-Related ProteinCreb-RpCamp-Responsive Element-Binding Protein-Like 1 Cleaved Into - Processed Cyclic Amp-Dependent Transcription Factor Atf-6 Beta |
| Database Links | Reactome: R-HSA-8874177 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Ii Membrane ProteinProcessed Cyclic Amp-Dependent Transcription Factor Atf-6 Beta: NucleusUnder Er Stress The Cleaved N-Terminal Cytoplasmic Domain Translocates Into The Nucleus |
| Alternative Antibody Names | Anti-Cyclic Amp-Dependent Transcription Factor Atf-6 Beta antibodyAnti-Camp-Dependent Transcription Factor Atf-6 Beta antibodyAnti-Activating Transcription Factor 6 Beta antibodyAnti-Atf6-Beta antibodyAnti-Protein G13 antibodyAnti-Camp Response Element-Binding Protein-Related Protein antibodyAnti-Creb-Rp antibodyAnti-Camp-Responsive Element-Binding Protein-Like 1 Cleaved Into - Processed Cyclic Amp-Dependent Transcription Factor Atf-6 Beta antibodyAnti-ATF6B antibodyAnti-CREBL1 antibodyAnti-G13 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
