Anti-ATF6B antibody (401-450 aa) (STJ91754)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human ATF6B at the amino acid range 401-450
General Information
| Short Description | Rabbit polyclonal anti-Cyclic AMP-dependent transcription factor ATF-6 beta (401-450 aa) for use in WB, IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000ELISA 1:20000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ATF6B |
| Gene ID | 1388 |
| Uniprot ID | ATF6B_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human ATF6B at the amino acid range 401-450 |
| Immunogen Region | 401-450 aa |
| Specificity | ATF-6 Beta Polyclonal Antibody detects endogenous levels of ATF-6 Beta protein. |
Additional Info
| Post Translational Modifications | N-glycosylated. During unfolded protein response, a fragment of approximately 60 kDa containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage is probably performed sequentially by site-1 (MBTPS1, S1P) and site-2 (MBTPS2, S2P) proteases. |
| Function | Cyclic AMP-dependent transcription factor ATF-6 beta: Precursor of the transcription factor form (Processed cyclic AMP-dependent transcription factor ATF-6 beta), which is embedded in the endoplasmic reticulum membrane. Endoplasmic reticulum stress promotes processing of this form, releasing the transcription factor form that translocates into the nucleus, where it activates transcription of genes involved in the unfolded protein response (UPR). Processed cyclic AMP-dependent transcription factor ATF-6 beta: Transcription factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER stress. Binds DNA on the 5'-CCACGA-3' half of the ER stress response element (ERSE) (5'-CCAATN(9)CCACGA-3') when NF-Y is bound to ERSE. |
| Protein Name | Cyclic Amp-Dependent Transcription Factor Atf-6 BetaCamp-Dependent Transcription Factor Atf-6 BetaActivating Transcription Factor 6 BetaAtf6-BetaProtein G13Camp Response Element-Binding Protein-Related ProteinCreb-RpCamp-Responsive Element-Binding Protein-Like 1 Cleaved Into - Processed Cyclic Amp-Dependent Transcription Factor Atf-6 Beta |
| Database Links | Reactome: R-HSA-8874177 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Ii Membrane ProteinProcessed Cyclic Amp-Dependent Transcription Factor Atf-6 Beta: NucleusUnder Er Stress The Cleaved N-Terminal Cytoplasmic Domain Translocates Into The Nucleus |
| Alternative Antibody Names | Anti-Cyclic Amp-Dependent Transcription Factor Atf-6 Beta antibodyAnti-Camp-Dependent Transcription Factor Atf-6 Beta antibodyAnti-Activating Transcription Factor 6 Beta antibodyAnti-Atf6-Beta antibodyAnti-Protein G13 antibodyAnti-Camp Response Element-Binding Protein-Related Protein antibodyAnti-Creb-Rp antibodyAnti-Camp-Responsive Element-Binding Protein-Like 1 Cleaved Into - Processed Cyclic Amp-Dependent Transcription Factor Atf-6 Beta antibodyAnti-ATF6B antibodyAnti-CREBL1 antibodyAnti-G13 antibody |
Information sourced from Uniprot.org