| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ATF3 |
| Gene ID: | 467 |
| Uniprot ID: | ATF3_HUMAN |
| Immunogen Region: | 1-181 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-181 of human ATF3 (NP_001665.1). |
| Immunogen Sequence: | MMLQHPGQVSASEVSASAIV PCLSPPGSLVFEDFANLTPF VKEELRFAIQNKHLCHRMSS ALESVTVSDRPLGVSITKAE VAPEEDERKKRRRERNKIAA AKCRNKKKEKTECLQKESEK LESVNAELKAQIEELKNEKQ HLIYMLNLHRPTCIVRAQNG RTPEDERNLFIQQIKEGTLQ S |
| Function | This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGTACAG-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2: Activates transcription presumably by sequestering inhibitory cofactors away from the promoters. Isoform 3: Stress-induced isoform, counteracts the transcriptional repression of isoform 1. |
| Protein Name | Cyclic Amp-Dependent Transcription Factor Atf-3Camp-Dependent Transcription Factor Atf-3Activating Transcription Factor 3 |
| Database Links | Reactome: R-HSA-380994Reactome: R-HSA-9633012Reactome: R-HSA-9648895 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Cyclic Amp-Dependent Transcription Factor Atf-3 antibodyAnti-Camp-Dependent Transcription Factor Atf-3 antibodyAnti-Activating Transcription Factor 3 antibodyAnti-ATF3 antibody |
Information sourced from Uniprot.org