Anti-ASXL2 antibody (1200-1275) {FITC} (STJ506155)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationFITC
IsotypeIgG
ImmunogenSynthetic peptide taken within amino acid region 1200-1275 on mouse Putative Polycomb group protein ASXL2.
General Information
| Short Description | Rabbit polyclonal antibody anti-ASXL2 (1200-1275) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications. |
| Applications | ELISA/IP/WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | FITC |
| Concentration | 0.5-1.5 µg/µl |
| Purification | Affinity Purified |
| Dilution Range | WB: 1:500-1:5, 000ELISA: 1:50, 000IP: 1:200 |
| Formulation | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | Asxl2 |
| Gene ID | 75302 |
| Uniprot ID | ASXL2_MOUSE |
| Immunogen | Synthetic peptide taken within amino acid region 1200-1275 on mouse Putative Polycomb group protein ASXL2. |
| Immunogen Region | 1200-1275 |
Additional Info
| Function | Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility. Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated receptor gamma (PPARG). Acts as a coactivator for PPARG and enhances its adipocyte differentiation-inducing activity.the function seems to involve differential recruitment of acetylated and methylated histone H3. Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability. ASXL1, ASXL2 and ASXL3 function redundantly in the PR-DUB complex. The ASXL proteins are essential for chromatin recruitment and transcriptional activation of associated genes. ASXL1 and ASXL2 are important for BAP1 protein stability. |
| Protein Name | Putative Polycomb Group Protein Asxl2Additional Sex Combs-Like Protein 2 |
| Database Links | Reactome: R-MMU-5689603 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Putative Polycomb Group Protein Asxl2 antibodyAnti-Additional Sex Combs-Like Protein 2 antibodyAnti-Asxl2 antibodyAnti-Kiaa1685 antibody |
Information sourced from Uniprot.org