| Function | Forms voltage-independent, pH-gated heterotrimeric sodium channels that act as postsynaptic excitatory receptors in the nervous system. Upon extracellular acidification, these channels generate a biphasic current with a fast inactivating and a slow sustained phase. ASIC3 is more sensitive to protons and gates between closed, open, and desensitized states faster than other ASICs. Displays high selectivity for sodium ions but can also permit the permeation of other cations. As a neuronal acid sensor, probably contributes to mechanoreception, acid nociception, and heat nociception. By forming heterotrimeric channels with ASIC2, generates a biphasic current with a fast inactivating and a slow sustained phase, which in sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissues. |
| Protein Name | Acid-Sensing Ion Channel 3Asic3Amiloride-Sensitive Cation Channel 3Dorsal Root AsicDrasic |
| Database Links | Reactome: R-MMU-2672351 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCytoplasmPreferentially Expressed At The Plasma Membrane Of The Soma And Cellular Processes Of NeuronsIn Part Cytoplasmic In Cochlea CellsLocalized In Specialized Sensory Nerve Endings |
| Alternative Antibody Names | Anti-Acid-Sensing Ion Channel 3 antibodyAnti-Asic3 antibodyAnti-Amiloride-Sensitive Cation Channel 3 antibodyAnti-Dorsal Root Asic antibodyAnti-Drasic antibodyAnti-Asic3 antibodyAnti-Accn3 antibodyAnti-Drasic antibody |
Information sourced from Uniprot.org
