| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:1000-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
ASH1L |
| Gene ID: |
55870 |
| Uniprot ID: |
ASH1L_HUMAN |
| Immunogen Region: |
2074-2293 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 2074-2293 of human ASH1L (NP_060959.2). |
| Immunogen Sequence: |
SNVYVDVKPLSGYEATTCNC KKPDDDTRKGCVDDCLNRMI FAECSPNTCPCGEQCCNQRI QRHEWVQCLERFRAEEKGWG IRTKEPLKAGQFIIEYLGEV VSEQEFRNRMIEQYHNHSDH YCLNLDSGMVIDSYRMGNEA RFINHSCDPNCEMQKWSVNG VYRIGLYALKDMPAGTELTY DYNFHSFNVEKQQLCKCGFE KCRGIIGGKSQRVNGLTSSK |
| Tissue Specificity | Widely expressed, with highest level in brain, heart and kidney. |
| Post Translational Modifications | Methylated at Gln-1220 by N6AMT1. |
| Function | Histone methyltransferase specifically trimethylating 'Lys-36' of histone H3 forming H3K36me3. Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. The physiological significance of the H3K9me1 activity is unclear. |
| Protein Name | Histone-Lysine N-Methyltransferase Ash1lAsh1-Like ProteinHuash1Absent Small And Homeotic Disks Protein 1 HomologLysine N-Methyltransferase 2h |
| Database Links | Reactome: R-HSA-3214841 |
| Cellular Localisation | NucleusCell JunctionTight JunctionChromosomeThe Relevance Of Tight Junction Localization Is However Unclear |
| Alternative Antibody Names | Anti-Histone-Lysine N-Methyltransferase Ash1l antibodyAnti-Ash1-Like Protein antibodyAnti-Huash1 antibodyAnti-Absent Small And Homeotic Disks Protein 1 Homolog antibodyAnti-Lysine N-Methyltransferase 2h antibodyAnti-ASH1L antibodyAnti-KIAA1420 antibodyAnti-KMT2H antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
