• Immunofluorescence analysis of paraffin-embedded mouse liver using ASGR1 Rabbit polyclonal antibody (STJ115244) at dilution of 1:100 (40x lens). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.
  • Immunofluorescence analysis of paraffin-embedded human liver cancer using ASGR1 Rabbit polyclonal antibody (STJ115244) at dilution of 1:100 (40x lens). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.
  • Immunofluorescence analysis of paraffin-embedded rat liver using ASGR1 Rabbit polyclonal antibody (STJ115244) at dilution of 1:100 (40x lens). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.
  • Immunohistochemistry analysis of ASGR1 in paraffin-embedded human liver cancer using ASGR1 Rabbit polyclonal antibody (STJ115244) at dilution of 1:200 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with immunohistochemistry staining protocol.
  • Immunohistochemistry analysis of ASGR1 in paraffin-embedded rat liver using ASGR1 Rabbit polyclonal antibody (STJ115244) at dilution of 1:200 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with immunohistochemistry staining protocol.
  • Western blot analysis of various lysates using ASGR1 Rabbit polyclonal antibody (STJ115244) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.

Anti-ASGR1 antibody (62-609) (STJ115244)

SKU:
STJ115244

£112.50 - £522.50
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Host: Rabbit
Applications: WB/IHC/IF
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-ASGR1 (62-609) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IHC-P 1:50-1:200
IF/ICC 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ASGR1
Gene ID: 432
Uniprot ID: ASGR1_HUMAN
Immunogen Region: 62-609
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 62-609 of human ASGR1 (NP_001125.1).
Immunogen Sequence: EVSKMVKDALTAIEKPTGDE QSSGCLENQLPAFLEELCHE KEILEKYGHSDCCSQSEEGR HNCFLAHKKPTPASIPLFQV PEPVTSCEAYEEDRETFMNK FIYEIARRHPFLYAPTILLW AARYDKIIPSCCKAENAVEC FQTKAATVTKELRESSLLNQ HACAVMKNFGTRTFQAITVT KLSQKFTKVNFTEIQKLVLD VAHVHEHCCRGDVLDCLQDG EKIMSYICSQ
Tissue Specificity Expressed exclusively in hepatic parenchymal cells.
Post Translational Modifications Phosphorylated on a cytoplasmic Ser residue.
Function Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.
Protein Name Asialoglycoprotein Receptor 1
Asgp-R 1
Asgpr 1
C-Type Lectin Domain Family 4 Member H1
Hepatic Lectin H1
Hl-1
Database Links Reactome: R-HSA-446203
Cellular Localisation Isoform H1a: Membrane
Single-Pass Type Ii Membrane Protein
Isoform H1b: Secreted
Alternative Antibody Names Anti-Asialoglycoprotein Receptor 1 antibody
Anti-Asgp-R 1 antibody
Anti-Asgpr 1 antibody
Anti-C-Type Lectin Domain Family 4 Member H1 antibody
Anti-Hepatic Lectin H1 antibody
Anti-Hl-1 antibody
Anti-ASGR1 antibody
Anti-CLEC4H1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance