| Tissue Specificity | Expressed exclusively in hepatic parenchymal cells. |
| Post Translational Modifications | Phosphorylated on a cytoplasmic Ser residue. |
| Function | Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface. |
| Protein Name | Asialoglycoprotein Receptor 1Asgp-R 1Asgpr 1C-Type Lectin Domain Family 4 Member H1Hepatic Lectin H1Hl-1 |
| Database Links | Reactome: R-HSA-446203 |
| Cellular Localisation | Isoform H1a: MembraneSingle-Pass Type Ii Membrane ProteinIsoform H1b: Secreted |
| Alternative Antibody Names | Anti-Asialoglycoprotein Receptor 1 antibodyAnti-Asgp-R 1 antibodyAnti-Asgpr 1 antibodyAnti-C-Type Lectin Domain Family 4 Member H1 antibodyAnti-Hepatic Lectin H1 antibodyAnti-Hl-1 antibodyAnti-ASGR1 antibodyAnti-CLEC4H1 antibody |
Information sourced from Uniprot.org
