| Host: | Mouse |
| Applications: | ELISA/WB/IF |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-Artemin is suitable for use in ELISA, Western Blot and Immunofluorescence research applications. |
| Clonality : | Monoclonal |
| Clone ID : | 2A5 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Formulation: | PBS pH 7.4, with 0.1% sodium azide |
| Purification: | Protein G purification |
| Dilution Range: | ELISA 0.2 to 1 µg/ml; WB 0.5 to 2 µg/ml (detects only dimeric protein in non-reducing conditions) ; IF 0.3 to 20 µg/ml. Monoclonal antibody working titer has to be established practically for each particular antigen and assay format |
| Storage Instruction: | Store at-20 to-70°C upon receipt. Divide antibody into aliquots prior usage. Avoid multiple freeze-thaw cycles |
| Gene Symbol: | ARTN |
| Gene ID: | 9048 |
| Uniprot ID: | ARTN_HUMAN |
| Specificity: | Human Artemin |
| Immunogen: | Recombinant human Artemin protein produced using CHO-based proprietary suspension cell line. Immunogen is purified from cell culture supernatant. Human Artemin |
| Tissue Specificity | Ubiquitous. Expressed at high levels in peripheral tissues including prostate, placenta, pancreas, heart, kidney, pituitary gland, lung and testis. Expressed at low levels in the brain. |
| Function | Growth factor that supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Acts by binding to its coreceptor, GFRA3, leading to autophosphorylation and activation of the RET receptor. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. |
| Protein Name | ArteminEnovinNeublastin |
| Database Links | Reactome: R-HSA-419037Reactome: R-HSA-5673001Reactome: R-HSA-8853659 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Artemin antibodyAnti-Enovin antibodyAnti-Neublastin antibodyAnti-ARTN antibodyAnti-EVN antibody |
Information sourced from Uniprot.org
