| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Arylsulfatase K (481-530 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:20000IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ARSK |
| Gene ID: | 153642 |
| Uniprot ID: | ARSK_HUMAN |
| Immunogen Region: | 481-530 aa |
| Specificity: | Arylsulfatase K Polyclonal Antibody detects endogenous levels of Arylsulfatase K protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human ARSK at the amino acid range 481-530 |
| Post Translational Modifications | The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. The 75-kDa precursor undergoes proteolytic processing to yield a 23 kDa form. N-glycosylated with both high mannose and complex type sugars. |
| Function | Catalyzes the hydrolysis of pseudosubstrates such as p-nitrocatechol sulfate and p-nitrophenyl sulfate. Catalyzes the hydrolysis of the 2-sulfate groups of the 2-O-sulfo-D-glucuronate residues of chondroitin sulfate, heparin and heparitin sulfate. Acts selectively on 2-sulfoglucuronate and lacks activity against 2-sulfoiduronate. |
| Protein Name | Arylsulfatase KAskGlucuronate-2-SulfataseTelethon Sulfatase |
| Database Links | Reactome: R-HSA-1663150Reactome: R-HSA-9840310 |
| Cellular Localisation | SecretedLysosome |
| Alternative Antibody Names | Anti-Arylsulfatase K antibodyAnti-Ask antibodyAnti-Glucuronate-2-Sulfatase antibodyAnti-Telethon Sulfatase antibodyAnti-ARSK antibodyAnti-TSULF antibodyAnti-UNQ630 antibodyAnti-PRO1246 antibody |
Information sourced from Uniprot.org