| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | Arsk |
| Gene ID: | 77041 |
| Uniprot ID: | ARSK_MOUSE |
| Immunogen Region: | 18-553 aa |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 18-553 of human Arsk (NP_084123.3). |
| Immunogen Sequence: | APRTQKKRMQVNQAPNVVLV ASDSFDGRLTFQPGSQVVKL PFINFMRAHGTTFLNAYTNS PICCPSRAAMWSGLFTHLTE SWNNFKGLDPNYTTWMDIME KHGYQTQKFGKVDYTSGHHS ISNRVEAWTRDVAFLLRQEG RPIINLIPDKNRRRVMTKDW QNTDKAIEWLRQVNYTKPFV LYLGLNLPHPYPSPSSGENF GSSTFHTSLYWLEKVAYDAI KIPKWLTLSQMHPVDFYSS |
| Post Translational Modifications | The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. The 75-kDa precursor undergoes proteolytic processing to yield a 23 kDa form. N-glycosylated with both high mannose and complex type sugars. |
| Function | Catalyzes the hydrolysis of pseudosubstrates such as p-nitrocatechol sulfate and p-nitrophenyl sulfate. Catalyzes the hydrolysis of the 2-sulfate groups of the 2-O-sulfo-D-glucuronate residues of chondroitin sulfate, heparin and heparitin sulfate. Acts selectively on 2-sulfoglucuronate and lacks activity against 2-sulfoiduronate. |
| Protein Name | Arylsulfatase KAskGlucuronate-2-Sulfatase |
| Database Links | Reactome: R-MMU-1663150Reactome: -MMU-9840310 |
| Cellular Localisation | SecretedLysosome |
| Alternative Antibody Names | Anti-Arylsulfatase K antibodyAnti-Ask antibodyAnti-Glucuronate-2-Sulfatase antibodyAnti-Arsk antibody |
Information sourced from Uniprot.org
