| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ARSA |
| Gene ID: | 410 |
| Uniprot ID: | ARSA_HUMAN |
| Immunogen Region: | 210-509 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 210-509 of human ARSA (NP_000478.3). |
| Immunogen Sequence: | LMADAQRQDRPFFLYYASHH THYPQFSGQSFAERSGRGPF GDSLMELDAAVGTLMTAIGD LGLLEETLVIFTADNGPETM RMSRGGCSGLLRCGKGTTYE GGVREPALAFWPGHIAPGVT HELASSLDLLPTLAALAGAP LPNVTLDGFDLSPLLLGTGK SPRQSLFFYPSYPDEVRGVF AVRTGKYKAHFFTQGSAHSD TTADPACHASSSLTAHEPPL LYDLSKDPGENYNLLGGVA |
| Post Translational Modifications | The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. This post-translational modification is severely defective in multiple sulfatase deficiency (MSD). |
| Function | Hydrolyzes cerebroside sulfate. |
| Protein Name | Arylsulfatase AAsaCerebroside-Sulfatase Cleaved Into - Arylsulfatase A Component B - Arylsulfatase A Component C |
| Database Links | Reactome: R-HSA-1663150Reactome: R-HSA-6798695Reactome: R-HSA-9840310 |
| Cellular Localisation | Endoplasmic ReticulumLysosome |
| Alternative Antibody Names | Anti-Arylsulfatase A antibodyAnti-Asa antibodyAnti-Cerebroside-Sulfatase Cleaved Into - Arylsulfatase A Component B - Arylsulfatase A Component C antibodyAnti-ARSA antibody |
Information sourced from Uniprot.org