| Host: | Rabbit |
| Applications: | WB/IF/ICC/IP/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S5MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 IF/ICC:1:50-1:200 IP:0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cells ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ARPC2 |
| Gene ID: | 10109 |
| Uniprot ID: | ARPC2_HUMAN |
| Immunogen Region: | 200-300 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 200-300 of human ARPC2 (O15144). |
| Immunogen Sequence: | FSHREPPLELKDTDAAVGDN IGYITFVLFPRHTNASARDN TINLIHTFRDYLHYHIKCSK AYIHTRMRAKTSDFLKVLNR ARPDAEKKEMKTITGKTFSS R |
| Function | Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the mother actin filament. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). |
| Protein Name | Actin-Related Protein 2/3 Complex Subunit 2 Arp2/3 Complex 34 Kda Subunit P34-Arc |
| Database Links | Reactome: R-HSA-2029482 Reactome: R-HSA-3928662 Reactome: R-HSA-5663213 Reactome: R-HSA-8856828 Reactome: R-HSA-9664422 |
| Cellular Localisation | Cytoplasm Cytoskeleton Cell Projection Synapse Synaptosome Nucleus |
| Alternative Antibody Names | Anti-Actin-Related Protein 2/3 Complex Subunit 2 antibody Anti-Arp2/3 Complex 34 Kda Subunit antibody Anti-P34-Arc antibody Anti-ARPC2 antibody Anti-ARC34 antibody Anti-PRO2446 antibody |
Information sourced from Uniprot.org