| Host: | Rabbit |
| Applications: | WB/IP/ICC |
| Reactivity: | Chicken/Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Arpc1b/p41-Arc (C-Term) is suitable for use in Western Blot, Immunoprecipitation and Immunocytochemistry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol |
| Purification: | Antigen Affinity Purified |
| Dilution Range: | WB 1:1000 ICC 1:200 IP 1:100 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ARPC1B |
| Gene ID: | 10095 |
| Uniprot ID: | ARC1B_HUMAN |
| Immunogen Region: | C-Term |
| Specificity: | The antibody detects a 41 kDa* protein corresponding to the molecular mass of Arpc1b on SDS-PAGE immunoblots of human A431 and Jurkat cells, rat A7r5 and PC12 cells, and mouse C2C12 cells. |
| Immunogen: | Arpc1b/p41-Arc synthetic peptide (coupled to KLH) corresponding to amino acid residues in the C-terminal region of human Arpc1b. This peptide sequence is highly conserved in rat, mouse, and chicken Arpc1b, and has some homology to the conserved regio |
| Function | Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). |
| Protein Name | Actin-Related Protein 2/3 Complex Subunit 1b Arp2/3 Complex 41 Kda Subunit P41-Arc |
| Database Links | Reactome: R-HSA-2029482 Reactome: R-HSA-3928662 Reactome: R-HSA-5663213 Reactome: R-HSA-9664422 |
| Cellular Localisation | Cytoplasm Cytoskeleton Nucleus |
| Alternative Antibody Names | Anti-Actin-Related Protein 2/3 Complex Subunit 1b antibody Anti-Arp2/3 Complex 41 Kda Subunit antibody Anti-P41-Arc antibody Anti-ARPC1B antibody Anti-ARC41 antibody |
Information sourced from Uniprot.org