Anti-ARNO/cytohesin 2 antibody (N-Term) (STJ71371)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-ARNO/cytohesin 2 (N-Term) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Dog |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:32000.WB: Approx 48kDa band observed in Human Brain (Cerebellum) lysates (calculated MW of 46.5kDa according to NP_004219.2 and NP_059431.1). Recommended concentration: 0.5-1.5µg/ml. |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | CYTH2 |
| Gene ID | 9266 |
| Uniprot ID | CYH2_HUMAN |
| Accession Number | NP_004219.2; NP_059431.1 |
| Immunogen Region | N-Term |
| Immunogen Sequence | EDGVYEPPDLTP |
| Specificity | This antibody is expected to recognise both reported isoforms (NP_004219.2; NP_059431.1). |
Additional Info
| Function | Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Activates ARF factors through replacement of GDP with GTP. The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane. Involved in neurite growth. |
| Protein Name | Cytohesin-2Arf Exchange FactorArf Nucleotide-Binding Site OpenerProtein ArnoPh - Sec7 And Coiled-Coil Domain-Containing Protein 2 |
| Database Links | Reactome: R-HSA-6811438 |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinCytoplasmCell ProjectionGrowth ConeCell JunctionTight JunctionAdherens JunctionBoth Isoform 1 And Isoform 2 Are Recruited To The Cell Membrane Through Its Association With Arl4aArl4c And Arl4dThey Require Also Interaction With Phosphoinositides For Targeting To Plasma MembraneIn Differentiating Neuroblastoma CellsColocalizes With Ccdc120 In Both Neurite Shaft And Growth Cone Areas |
| Alternative Antibody Names | Anti-Cytohesin-2 antibodyAnti-Arf Exchange Factor antibodyAnti-Arf Nucleotide-Binding Site Opener antibodyAnti-Protein Arno antibodyAnti-Ph - Sec7 And Coiled-Coil Domain-Containing Protein 2 antibodyAnti-CYTH2 antibodyAnti-ARNO antibodyAnti-PSCD2 antibodyAnti-PSCD2L antibody |
Information sourced from Uniprot.org