| Function | Substrate-recognition component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The BCR(ARMC5) complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the BCR(ARMC5) complex acts by mediating ubiquitination of Pol II subunit POLR2A phosphorylated at 'Ser-5' of the C-terminal domain (CTD), leading to POLR2A degradation. The BCR(ARMC5) complex acts in parallel of the integrator complex and is specific for RNA Pol II originating from the promoter-proximal zone: it does not ubiquitinate elongation-stalled RNA Pol II. The BCR(ARMC5) complex also acts as a regulator of fatty acid desaturation by mediating ubiquitination and degradation of SCAP-free SREBF1 and SREBF2. Involved in fetal development, T-cell function and adrenal gland growth homeostasis. Plays a role in steroidogenesis, modulates steroidogenic enzymes expression and cortisol production. |
| Protein Name | Armadillo Repeat-Containing Protein 5 |
| Database Links | |
| Cellular Localisation | NucleusChromosomeCytoplasmAssociates To Rna Polymerase Ii (Pol Ii) On Chromatin |
| Alternative Antibody Names | Anti-Armadillo Repeat-Containing Protein 5 antibodyAnti-ARMC5 antibody |
Information sourced from Uniprot.org
