| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:200-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ARL1 |
| Gene ID: | 400 |
| Uniprot ID: | ARL1_HUMAN |
| Immunogen Region: | 62-181 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 62-181 of human ARL1 (NP_001168.1). |
| Immunogen Sequence: | KFQVWDLGGQTSIRPYWRCY YSNTDAVIYVVDSCDRDRIG ISKSELVAMLEEEELRKAIL VVFANKQDMEQAMTSSEMAN SLGLPALKDRKWQIFKTSAT KGTGLDEAMEWLVETLKSRQ |
| Tissue Specificity | Detected in heart, liver, lung and liver (at protein level). Detected in fetal heart, lung, liver and kidney. Detected in adult heart, placenta, lung, liver, skeletal muscle, kidney and pancreas. |
| Function | GTP-binding protein that recruits several effectors, such as golgins, arfaptins and Arf-GEFs to the trans-Golgi network, and modulates their functions at the Golgi complex. Plays thereby a role in a wide range of fundamental cellular processes, including cell polarity, innate immunity, or protein secretion mediated by arfaptins, which were shown to play a role in maintaining insulin secretion from pancreatic beta cells. |
| Protein Name | Adp-Ribosylation Factor-Like Protein 1 |
| Database Links | Reactome: R-HSA-6811440 |
| Cellular Localisation | Golgi Apparatus MembranePeripheral Membrane ProteinCytoplasmic SideGolgi ApparatusTrans-Golgi Network MembraneMembraneLipid-Anchor |
| Alternative Antibody Names | Anti-Adp-Ribosylation Factor-Like Protein 1 antibodyAnti-ARL1 antibody |
Information sourced from Uniprot.org