| Tissue Specificity | Highly expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon, and PBL, and at a much lower level in heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas. |
| Function | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. |
| Protein Name | At-Rich Interactive Domain-Containing Protein 1aArid Domain-Containing Protein 1aB120Brg1-Associated Factor 250Baf250Brg1-Associated Factor 250aBaf250aOsa Homolog 1Hosa1Swi-Like ProteinSwi/Snf Complex Protein P270Swi/Snf-Related - Matrix-Associated - Actin-Dependent Regulator Of Chromatin Subfamily F Member 1Held |
| Database Links | Reactome: R-HSA-3214858Reactome: R-HSA-8939243Reactome: R-HSA-9824585Reactome: R-HSA-9845323 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-At-Rich Interactive Domain-Containing Protein 1a antibodyAnti-Arid Domain-Containing Protein 1a antibodyAnti-B120 antibodyAnti-Brg1-Associated Factor 250 antibodyAnti-Baf250 antibodyAnti-Brg1-Associated Factor 250a antibodyAnti-Baf250a antibodyAnti-Osa Homolog 1 antibodyAnti-Hosa1 antibodyAnti-Swi-Like Protein antibodyAnti-Swi/Snf Complex Protein P270 antibodyAnti-Swi/Snf-Related - Matrix-Associated - Actin-Dependent Regulator Of Chromatin Subfamily F Member 1 antibodyAnti-Held antibodyAnti-ARID1A antibodyAnti-BAF250 antibodyAnti-BAF250A antibodyAnti-C1orf4 antibodyAnti-OSA1 antibodyAnti-SMARCF1 antibody |
Information sourced from Uniprot.org
