• Western blot analysis of lysates from rat muscle and rat heart cells, using ARHGEF7 Antibody. The lane on the right is blocked with the synthesized peptide.

Anti-ARHGEF7 antibody (311-360 aa) (STJ95106)

SKU:
STJ95106

Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Rho guanine nucleotide exchange factor 7 (311-360 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:5000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ARHGEF7
Gene ID: 8874
Uniprot ID: ARHG7_HUMAN
Immunogen Region: 311-360 aa
Specificity: PIX Beta Polyclonal Antibody detects endogenous levels of PIX Beta protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human ARHGEF7 at the amino acid range 311-360
Function Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions. May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons.
Protein Name Rho Guanine Nucleotide Exchange Factor 7
Beta-Pix
Cool-1
Pak-Interacting Exchange Factor Beta
P85
Database Links Reactome: R-HSA-182971
Reactome: R-HSA-193648
Reactome: R-HSA-3928664
Reactome: R-HSA-416482
Reactome: R-HSA-8980692
Reactome: R-HSA-9013148
Reactome: R-HSA-9013149
Reactome: R-HSA-9013406
Reactome: R-HSA-9013409
Reactome: R-HSA-9013420
Reactome: R-HSA-9013424
Reactome: R-HSA-9619229 Q14155-1
Cellular Localisation Cell Junction
Focal Adhesion
Cell Projection
Ruffle
Cytoplasm
Cell Cortex
Lamellipodium
Detected At Cell Adhesions
A Small Proportion Is Detected At Focal Adhesions
Alternative Antibody Names Anti-Rho Guanine Nucleotide Exchange Factor 7 antibody
Anti-Beta-Pix antibody
Anti-Cool-1 antibody
Anti-Pak-Interacting Exchange Factor Beta antibody
Anti-P85 antibody
Anti-ARHGEF7 antibody
Anti-COOL1 antibody
Anti-KIAA0142 antibody
Anti-P85SPR antibody
Anti-PAK3BP antibody
Anti-PIXB antibody
Anti-Nbla10314 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance