Anti-ARHGEF5 antibody (1280-1330 aa) (STJ94826)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human ARHGEF5 at the amino acid range 1280-1330
General Information
| Short Description | Rabbit polyclonal anti-Rho guanine nucleotide exchange factor 5 (1280-1330 aa) for use in WB and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000ELISA 1:20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ARHGEF5 |
| Gene ID | 7984 |
| Uniprot ID | ARHG5_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human ARHGEF5 at the amino acid range 1280-1330 |
| Immunogen Region | 1280-1330 aa |
| Specificity | Oncogene TIM Polyclonal Antibody detects endogenous levels of Oncogene TIM protein. |
Additional Info
| Post Translational Modifications | Activation of SRC induces tyrosine phosphorylation of ARHGEF5. |
| Function | Guanine nucleotide exchange factor which activates Rho GTPases. Strongly activates RHOA. Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1. Involved in regulation of cell shape and actin cytoskeletal organization. Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia. Required for SRC-induced podosome formation. Involved in positive regulation of immature dendritic cell migration. |
| Protein Name | Rho Guanine Nucleotide Exchange Factor 5Ephexin-3Guanine Nucleotide Regulatory Protein TimOncogene TimTransforming Immortalized Mammary OncogeneP60 Tim |
| Database Links | Reactome: R-HSA-193648Reactome: R-HSA-416482Reactome: R-HSA-8980692Reactome: R-HSA-9013026Reactome: R-HSA-9013106Reactome: R-HSA-9013148Reactome: R-HSA-9013149Reactome: R-HSA-9013408 |
| Cellular Localisation | CytoplasmNucleusCell ProjectionPodosome |
| Alternative Antibody Names | Anti-Rho Guanine Nucleotide Exchange Factor 5 antibodyAnti-Ephexin-3 antibodyAnti-Guanine Nucleotide Regulatory Protein Tim antibodyAnti-Oncogene Tim antibodyAnti-Transforming Immortalized Mammary Oncogene antibodyAnti-P60 Tim antibodyAnti-ARHGEF5 antibodyAnti-TIM antibody |
Information sourced from Uniprot.org