| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
ARHGEF28 |
| Gene ID: |
64283 |
| Uniprot ID: |
ARG28_HUMAN |
| Immunogen Region: |
1050-1250 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1050-1250 of human ARHGEF28 (NP_001073948.2). |
| Immunogen Sequence: |
KNQKWLEILNKIENKTYTKL KNGHVFRKQALMSEERTLLY DGLVYWKTATGRFKDILALL LTDVLLFLQEKDQKYIFAAV DQKPSVISLQKLIAREVANE ERGMFLISASSAGPEMYEIH TNSKEERNNWMRRIQQAVES CPEEKGGRTSESDEDKRKAE ARVAKIQQCQEILTNQDQQI CAYLEEKLHIYAELGELSGF E |
| Post Translational Modifications | Phosphorylated on tyrosine upon stimulation of cells by laminin. |
| Function | Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Functions also in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis. |
| Protein Name | Rho Guanine Nucleotide Exchange Factor 28190 Kda Guanine Nucleotide Exchange FactorP190-RhogefP190rhogefRho Guanine Nucleotide Exchange Factor |
| Database Links | Reactome: R-HSA-3928662Reactome: R-HSA-8980692Reactome: R-HSA-9013026Reactome: R-HSA-9013106 |
| Cellular Localisation | CytoplasmCell MembraneColocalizes With The Microtubule Radial And Cortical Systems |
| Alternative Antibody Names | Anti-Rho Guanine Nucleotide Exchange Factor 28 antibodyAnti-190 Kda Guanine Nucleotide Exchange Factor antibodyAnti-P190-Rhogef antibodyAnti-P190rhogef antibodyAnti-Rho Guanine Nucleotide Exchange Factor antibodyAnti-ARHGEF28 antibodyAnti-KIAA1998 antibodyAnti-RGNEF antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
