Anti-ARHGEF28 antibody (1050-1250 aa) (STJ11105970)

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STJ11105970
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Gene Symbol: ARHGEF28
Gene ID: 64283
Uniprot ID: ARG28_HUMAN
Immunogen Region: 1050-1250 aa
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 1050-1250 of human ARHGEF28 (NP_001073948.2).
Immunogen Sequence: KNQKWLEILNKIENKTYTKL KNGHVFRKQALMSEERTLLY DGLVYWKTATGRFKDILALL LTDVLLFLQEKDQKYIFAAV DQKPSVISLQKLIAREVANE ERGMFLISASSAGPEMYEIH TNSKEERNNWMRRIQQAVES CPEEKGGRTSESDEDKRKAE ARVAKIQQCQEILTNQDQQI CAYLEEKLHIYAELGELSGF E
Post Translational Modifications Phosphorylated on tyrosine upon stimulation of cells by laminin.
Function Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Functions also in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis.
Protein Name Rho Guanine Nucleotide Exchange Factor 28
190 Kda Guanine Nucleotide Exchange Factor
P190-Rhogef
P190rhogef
Rho Guanine Nucleotide Exchange Factor
Database Links Reactome: R-HSA-3928662
Reactome: R-HSA-8980692
Reactome: R-HSA-9013026
Reactome: R-HSA-9013106
Cellular Localisation Cytoplasm
Cell Membrane
Colocalizes With The Microtubule Radial And Cortical Systems
Alternative Antibody Names Anti-Rho Guanine Nucleotide Exchange Factor 28 antibody
Anti-190 Kda Guanine Nucleotide Exchange Factor antibody
Anti-P190-Rhogef antibody
Anti-P190rhogef antibody
Anti-Rho Guanine Nucleotide Exchange Factor antibody
Anti-ARHGEF28 antibody
Anti-KIAA1998 antibody
Anti-RGNEF antibody

Information sourced from Uniprot.org

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