Anti-ARHGEF11 antibody (281-490 aa) [SRM5258] (STJ11107160)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal ARHGEF11 (281-490 aa) antibody for use in WB and ELISA in mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SRM5258 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ARHGEF11 |
| Gene ID | 9826 |
| Uniprot ID | ARHGB_HUMAN |
| Immunogen Region | 281-490 aa |
| Immunogen Sequence | QGVDQSPKPLIIGPEEDYDP GYFNNESDIIFQDLEKLKSR PAHLGVFLRYIFSQADPSPL LFYLCAEVYQQASPKDSRSL GKDIWNIFLEKNAPLRVKIP EMLQAEIDSRLRNSEDARGV LCEAQEAAMPEIQEQIHDYR TKRTLGLGSLYGENDLLDLD GDPLRERQVAEKQLAALGDI LSKYEEDRSAPMDFALNTYM SHAGIRLREA |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 281-490 of human ARHGEF11 (NP_055599.1). |
Additional Info
| Tissue Specificity | Ubiquitously expressed. |
| Post Translational Modifications | Phosphorylated by MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14). Ubiquitinated by the BCR(KLHL20) E3 ubiquitin ligase complex when previously phosphorylated by MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14), leading to its degradation, thereby restricting RhoA activity and facilitating growth cone spreading and neurite outgrowth. |
| Function | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth. |
| Protein Name | Rho Guanine Nucleotide Exchange Factor 11Pdz-Rhogef |
| Database Links | Reactome: R-HSA-193648Reactome: R-HSA-416482Reactome: R-HSA-416572Reactome: R-HSA-8980692Reactome: R-HSA-9013026Reactome: R-HSA-9013106Reactome: R-HSA-9013148Reactome: R-HSA-9013149 |
| Cellular Localisation | CytoplasmMembraneTranslocated To The Membrane Upon Stimulation |
| Alternative Antibody Names | Anti-Rho Guanine Nucleotide Exchange Factor 11 antibodyAnti-Pdz-Rhogef antibodyAnti-ARHGEF11 antibodyAnti-KIAA0380 antibody |
Information sourced from Uniprot.org