| Host: | Goat |
| Applications: | Pep-ELISA/WB |
| Reactivity: | Human/Mouse/Rat/Dog |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-Argininosuccinate synthetase 1, Biotinylated (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Biotin |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:64000.WB: Approx 46kDa band observed in Human Kidney lysates (calculated MW of 46.5kDa according to NP_000041.2). See non-biotinylated parental product's datasheet for further QC data. Recommend |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | ASS1 |
| Gene ID: | 445 |
| Uniprot ID: | ASSY_HUMAN |
| Immunogen Region: | Internal |
| Accession Number: | NP_000041.2 |
| Specificity: | Reported variants represent identical protein: NP_446464.1, NP_000041.2 |
| Immunogen Sequence: | ENPKNQAPPGLYTKTQD. |
| Post Translational Modifications | Acetylated by CLOCK in a circadian manner which negatively regulates its enzyme activity. Deacetylated by histone deacetylases. |
| Function | One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues. |
| Protein Name | Argininosuccinate SynthaseCitrulline--Aspartate Ligase |
| Database Links | Reactome: R-HSA-70635 |
| Cellular Localisation | CytoplasmCytosol |
| Alternative Antibody Names | Anti-Argininosuccinate Synthase antibodyAnti-Citrulline--Aspartate Ligase antibodyAnti-ASS1 antibodyAnti-ASS antibody |
Information sourced from Uniprot.org