| Host: | Rabbit |
| Applications: | IF/ICC/ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | AREG |
| Gene ID: | 374 |
| Uniprot ID: | AREG_HUMAN |
| Immunogen Region: | 20-252 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-252 of human AREG (NP_001648.1). |
| Immunogen Sequence: | SGHYAAGLDLNDTYSGKREP FSGDHSADGFEVTSRSEMSS GSEISPVSEMPSSSEPSSGA DYDYSEEYDNEPQIPGYIVD DSVRVEQVVKPPQNKTESEN TSDKPKRKKKGGKNGKNRRN RKKKNPCNAEFQNFCIHGEC KYIEHLEAVTCKCQQEYFGE RCGEKSMKTHSMIDSSLSKI ALAAIAAFMSAVILTAVAVI TVQLRRQYVRKYEGEAEERK KLRQENGNVHAIA |
| Function | Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts. |
| Protein Name | Amphiregulin Ar Colorectum Cell-Derived Growth Factor Crdgf |
| Database Links | Reactome: R-HSA-1257604 Reactome: R-HSA-177929 Reactome: R-HSA-179812 Reactome: R-HSA-180292 Reactome: R-HSA-180336 Reactome: R-HSA-182971 Reactome: R-HSA-204005 Reactome: R-HSA-212718 Reactome: R-HSA-2219530 Reactome: R-HSA-5638303 Reactome: R-HSA-5673001 Reactome: R-HSA-5694530 Reactome: R-HSA-6811558 Reactome: R-HSA-8856825 Reactome: R-HSA-8856828 Reactome: R-HSA-9009391 Reactome: R-HSA-9634638 Reactome: R-HSA-9818030 |
| Cellular Localisation | Membrane Single-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Amphiregulin antibody Anti-Ar antibody Anti-Colorectum Cell-Derived Growth Factor antibody Anti-Crdgf antibody Anti-AREG antibody Anti-AREGB antibody Anti-SDGF antibody |
Information sourced from Uniprot.org