Function | Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts on ARF6, RAC1, RHOA and CDC42. Plays a role in the internalization of anthrax toxin. |
Protein Name | Arf-Gap With Rho-Gap Domain - Ank Repeat And Ph Domain-Containing Protein 3Centaurin-Delta-3Cnt-D3 |
Database Links | Reactome: R-HSA-8980692Reactome: R-HSA-9013148Reactome: R-HSA-9013149Reactome: R-HSA-9013423 |
Cellular Localisation | CytoplasmCytoskeletonCell MembranePeripheral Membrane ProteinCell ProjectionLamellipodiumRuffleCytoplasmicAnd Associated With F-Actin-Rich Membrane Ruffles And Lamellipodia |
Alternative Antibody Names | Anti-Arf-Gap With Rho-Gap Domain - Ank Repeat And Ph Domain-Containing Protein 3 antibodyAnti-Centaurin-Delta-3 antibodyAnti-Cnt-D3 antibodyAnti-ARAP3 antibodyAnti-CENTD3 antibody |
Information sourced from Uniprot.org