| Host: | Goat |
| Applications: | Pep-ELISA/WB/IP |
| Reactivity: | Human/Mouse/Dog/Pig/Cow |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-ARAP3 (C-Term) is suitable for use in ELISA, Western Blot and Immunoprecipitation research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:4000.WB: This antibody has been successfully used in WB on scirrhous human gastric cancer cell lines.IP: This antibody has been successfully used in IP on scirrhous human gastric cancer cel |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | ARAP3 |
| Gene ID: | 64411 |
| Uniprot ID: | ARAP3_HUMAN |
| Immunogen Region: | C-Term |
| Accession Number: | NP_071926.4 |
| Immunogen Sequence: | CTSSPPSSQPLT |
| Function | Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts on ARF6, RAC1, RHOA and CDC42. Plays a role in the internalization of anthrax toxin. |
| Protein Name | Arf-Gap With Rho-Gap Domain - Ank Repeat And Ph Domain-Containing Protein 3Centaurin-Delta-3Cnt-D3 |
| Database Links | Reactome: R-HSA-8980692Reactome: R-HSA-9013148Reactome: R-HSA-9013149Reactome: R-HSA-9013423 |
| Cellular Localisation | CytoplasmCytoskeletonCell MembranePeripheral Membrane ProteinCell ProjectionLamellipodiumRuffleCytoplasmicAnd Associated With F-Actin-Rich Membrane Ruffles And Lamellipodia |
| Alternative Antibody Names | Anti-Arf-Gap With Rho-Gap Domain - Ank Repeat And Ph Domain-Containing Protein 3 antibodyAnti-Centaurin-Delta-3 antibodyAnti-Cnt-D3 antibodyAnti-ARAP3 antibodyAnti-CENTD3 antibody |
Information sourced from Uniprot.org